Perfil de Personalidad de un Grupo de Estudiantes de Citohistotecnología

By 2012, the National Ministry of Education in Colombia recognized 286 Institutions of Higher Education (IHEs) in the country that offered technical and technological programs. The quality of technicians, technologists, and other professionals is directly related to their performance during secondary and tertiary education. The aim of this paper is to describe the personality profile and academic performance of a group of Cytology and Histology students at a Health Sciences institution of higher education. We performed a descriptive study that included first to third semester students in the Department of Cytology and Histology. We measured socio-demographic variables related to academic achievement and the Gordon Personal Profile-Inventory (GPP-I) test results. This study was approved by the Ethics for Research on Humans Committee at the Fundación Universitaria de Ciencias de la Salud. We analyzed 53 Cytology and Histology students. The average age was 18 years old (IQR 18-21), and the gender distribution was 88.4% female (46/53). The initial grade mean was 3.5 (IQR: 3.3-3.8), with 5 being the maximum in the Colombian grading system, and the mid-career grade was 3.7 (IQR: 3.6-4). We explored the relationship between the place of residence before starting the program, the result of the National Test for Graduates in Colombia (ICFES-SABERPro, comparable to the American SAT), and the academic performance of students. We observed a significant correlation among these variables. Despite there being a number of university departments in the field in Colombia, Cytology/Histology is a poorly known profession, and the skills and abilities together with its range of tasks in the labor market are unknown. Concerning academic performance and its correlation with the GPP-I domains, we observed that there was a direct relationship between starting grade point average and original thinking.En Colombia para el año 2012 fueron reconocidas 286 Instituciones de Educación Superior (IES), las cuales ofertan programas técnicos y tecnológicos. La calidad de los técnicos, tecnólogos y profesionales está relacionada directamente con su desempeño durante el colegio y la carrera. Describir el perfil de personalidad y su desempeño académico de un grupo de estudiantes de Citohistología, en una institución de educación superior de ciencias de la salud. Se realizó un estudio descriptivo, donde se incluyeron estudiantes de primero a tercer semestre de la Facultad de Citohistotecnología. Se midieron variables sociodemográficas, relacionadas con el desempeño académico y resultados de la prueba de inventario de personalidad de Gordon (P-IPG). Este estudio fue aprobado por el comité de ética de investigación con seres humanos de la Fundación Universitaria de Ciencias de la Salud. Se analizaron 53 estudiantes de Citohistología, la mediana de edad fue de 18 años (RIQ: 18-21), la distribución por género fue 46 mujeres (88.4%). La mediana de notas al inicio de carrera fue de 3.5 (RIQ: 3.3-3.8), y mitad de carrera 3.7 (RIQ: 3.6-4). Se exploró la relación entre el lugar de vivienda antes de iniciar el pregrado, el resultado del ICFES-SABERPro y el rendimiento académico, observando una relación estadísticamente significativa. La Citohistotecnología actualmente es poco conocida a pesar de que existen varias facultades en Colombia y no se conoce claramente las destrezas y habilidades de su desempeño en el campo laboral. Con respecto al rendimiento académico y su correlación con los dominios del P-IPG, se observó que había una relación directamente proporcional entre el promedio inicial de carrera y la originalida

Reconstruction of vocal fold scarring with mesenchymal stromal cell therapy

Tissue injury/scarring of the vocal folds (VFs) can be caused by various factors including external trauma, cancer treatment or inflammation, leading to damage within the vibrating layers and a decrease in viscoelastic functions. These effects ultimately result in severe voice problems. This condition leads to significant morbidity for patients. Approximately 5-20% of the population in Western countries suffer from chronic hoarseness and/or a voice disorder. Currently, there are no effective treatments available. Embryonic stem cells (ESCs) are pluripotent cells that can different into various cell types or tissues in the body. They are powerful candidates for cell therapy for many diseases. Mesenchymal stromal cells (MSCs) have been considered as a valuable source in regenerative medicine due to their immunomodulatory properties, ability to self-renew and multipotency. The overall aim of this PhD project was to identify whether stem cells, and in particular local injection of MSCs can modulate the early inflammatory response within scarred VFs, and promote the wound healing process. We have used a combination of in vitro and in vivo models to address the fundamental questions, before translating our findings to a clinical phase I/II trial evaluating the safety and efficacy of autologous MSC injection on vocal function in patients suffering with severe voice problems. In study I, in a xenograft model, we showed that local injection of human embryonic stem cells (hESCs) induces sustained enhanced healing properties in injured VFs. Measurement of tissue viscoelasticity demonstrated improved function of VFs. Histological findings show a reduction in type I collagen and lamina propria (LP) thickness in hESC treated VFs compared to untreated VFs. Moreover, no hESCs derivates (teratoma and malignances) were observed in the transplanted VFs. In study II, we examined how MSCs modulate the early inflammatory response within injured rabbit VFs. Histological examination demonstrated that injected MSCs were able to reduce tissue inflammation, further corroborated by findings confirming a significant reduction in mRNA expression of the pro-inflammatory markers, interleukin (IL)-1β and IL- 8. These findings were attributed to the ability of MSCs to reduce the level of cell death at the injury site and promote an anti-inflammatory milieu, as evidenced by increased levels of CD163+ cells. Despite low level persistence of the MSCs within the tissue, long-term effects on tissue repair were evident, with improved organization of the collagen matrix. Limitations, in terms of cell suspension leakage and retention of MSCs at the site of injury have been reported with the use of liquid delivery vehicles. Study III therefore addressed these issues, evaluating the effectiveness of MSC delivery to injured VFs in a hyaluronan (HA) hydrogel carrier. Our findings demonstrated that HA was non-immunogenic, with no adverse events reported, and degraded within the VF tissue within 1 month. Complementary in vitro studies demonstrated that while the HA hydrogel delayed the migration of MSCs, these cells remained responsive to their extracellular environment, including proinflammatory cues. The presence of a collagen matrix, as seen within the VF tissue, enhanced movement out of the gel potentially explaining why hydrogel delivery did not enhance persistence of the MSCs in the tissue. The study concluded that HA hydrogels may offer a safe and practical means to deliver MSCs to the VF, with minimal leakage, but no additional therapeutic effect could be seen in comparison to MSCs in liquid suspension. Based on the findings from studies II and III, we performed a phase I/II clinical trial in 16 patients with severe VF scarring suffering from severe voice problems (study IV). Patients were treated with a single injection of autologous MSCs, after surgical resection of scar tissue. The study reached its primary endpoint of safety, with no adverse side effects reported. Clinical evaluation using high speed laryngoscopy and phonation pressure threshold demonstrated improvement in VF viscoelastic function in 62-75% of patients, dependent on the parameter. Self-reporting by the patients, using the voice handicap index confirmed significant improvements in phonation in 50% of the patients, with no significant change in the remaining cohort. In summary, stem cells and stromal cells were found to improve healing in scarred VFs. Local administration of MSCs into injured/scarred VFs dampens inflammatory responses by decreasing cell death due to injury and promoting an anti-inflammatory milieu. Delivery of the MSCs in a HA hydrogel reduces cell leakage, but does not offer therapeutic advantages compared to MSCs alone. Despite low-level persistence and no engraftment within the VF tissue, MSCs exerted long-term effects resulting in functional tissue repair. Our in vivo animal studies demonstrating the mechanisms by which MSCs support tissue repair were translated to the clinical setting, with local administration of autologous MSCs improving VF function and reducing morbidities associated with poor phonation in the treated patients. We conclude that local injection of MSCs may offer a safe and novel option for the treatment of VF scarring

University of Windsor Undergraduate Calendar 2000-2001

https://scholar.uwindsor.ca/universitywindsorundergraduatecalendars/1008/thumbnail.jp

2005 - 2006 University Catalog

This is a one-year CATALOG, effective beginning Summer Quarter 2005.https://scholarsrepository.llu.edu/univcatalog/1010/thumbnail.jp

2010 - 2011 University Catalog

Volume 100, Number 1, July 2010 Published once a year, July 2010https://scholarsrepository.llu.edu/univcatalog/1006/thumbnail.jp

Columbus State University Honors College: Senior Theses, Fall 2020/Spring 2021

This is a collection of senior theses written by honors students at Columbus State University during the Fall 2020 and Spring 2021 semesters.https://csuepress.columbusstate.edu/honors_theses/1002/thumbnail.jp

GVSU Undergraduate and Graduate Bulletin, 1997-1998

Grand Valley State University 1997-1998 undergraduate and/or graduate bulletin published annually to provide students with information and guidance for enrollment.https://scholarworks.gvsu.edu/course_catalogs/1064/thumbnail.jp

Personality Profile of a Group of Cyto-Histotechnology Students

 By 2012, the National Ministry of Education in Colombia recognized 286 Institutions of Higher Education (IHEs) in the country that offered technical and technological programs. The quality of technicians, technologists, and other professionals is directly related to their performance during secondary and tertiary education.  The aim of this paper is to describe the personality profile and academic performance of a group of Cytology and Histology students at a Health Sciences institution of higher education. We performed a descriptive study that included first to third semester students in the Department of Cytology and Histology. We measured socio-demographic variables related to academic achievement and the Gordon Personal Profile-Inventory (GPP-I) test results. This study was approved by the Ethics for Research on Humans Committee at the Fundación Universitaria de Ciencias de la Salud. We analyzed 53 Cytology and Histology students. The average age was 18 years old (IQR 18-21), and the gender distribution was 88.4% female (46/53). The initial grade mean was 3.5 (IQR: 3.3-3.8), with 5 being the maximum in the Colombian grading system, and the mid-career grade was 3.7 (IQR: 3.6-4). We explored the relationship between the place of residence before starting the program, the result of the National Test for Graduates in Colombia (ICFES-SABERPro, comparable to the American SAT), and the academic performance of students. We observed a significant correlation among these variables. Despite there being a number of university departments in the field in Colombia, Cytology/Histology is a poorly known profession, and the skills and abilities together with its range of tasks in the labor market are unknown. Concerning academic performance and its correlation with the GPP-I domains, we observed that there was a direct relationship between starting grade point average and original thinking